Internal radiotherapy dosimetry

Internal vectorised radiotherapy are promising therapeutic modalities, increasingly used in the treatment of unresectable tumors. Optimization of the therapeutic outcome by maximizing the dose delivered to the tumor, while keeping the dose delivered to organs at risk at acceptable levels is the main goal of dosimetry. Systematically implemented dosimetry is essential in order to fully exploit the therapeutic potential of internal vectorised radiotherapy. Furthermore, accurate and precise dosimetric estimations are crucial for establishing a correlation between absorbed dose and treatment efficacy and safety. However, accuracy and precision in dosimetry may be hampered by potential systematic and stochastic errors respectively. The aim of this project is to assess the potential errors committed on the dosimetric calculations and to evaluate their biological impact on tumor dose-response and organ dose-toxicity correlation.